Chemical Inhibition of Histone Deacetylases 1 and 2 Induces Fetal Hemoglobin through Activation of GATA2

Therapeutic intervention aimed at reactivation of fetal hemoglobin protein (HbF) is a promising approach for ameliorating sickle cell disease (SCD) and β-thalassemia. Previous studies showed genetic knockdown of histone deacetylase (HDAC) 1 or 2 is sufficient to induce HbF. Here we show that ACY-957...

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Detalles Bibliográficos
Autores principales: Shearstone, Jeffrey R., Golonzhka, Olga, Chonkar, Apurva, Tamang, David, van Duzer, John H., Jones, Simon S., Jarpe, Matthew B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830539/
https://www.ncbi.nlm.nih.gov/pubmed/27073918
http://dx.doi.org/10.1371/journal.pone.0153767

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830539/
https://www.ncbi.nlm.nih.gov/pubmed/27073918
http://dx.doi.org/10.1371/journal.pone.0153767

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