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Effect of pioglitazone treatment in a patient with secondary multiple sclerosis

BACKGROUND: Ligands of the peroxisome proliferator-activated receptor-gamma (PPARγ) induce apoptosis in activated T-lymphocytes and exert anti-inflammatory effects in glial cells. Preclinical studies have shown that the thiazolidinedione pioglitazone, an FDA-approved PPARγ agonist used to treat type...

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Detalles Bibliográficos
Autores principales: Pershadsingh, Harrihar A, Heneka, Michael T, Saini, Rashmi, Amin, Navin M, Broeske, Daniel J, Feinstein, Douglas L
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2004
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC483056/
https://www.ncbi.nlm.nih.gov/pubmed/15285799
http://dx.doi.org/10.1186/1742-2094-1-3