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Maximum-Entropy Models of Sequenced Immune Repertoires Predict Antigen-Antibody Affinity
The immune system has developed a number of distinct complex mechanisms to shape and control the antibody repertoire. One of these mechanisms, the affinity maturation process, works in an evolutionary-like fashion: after binding to a foreign molecule, the antibody-producing B-cells exhibit a high-fr...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830580/ https://www.ncbi.nlm.nih.gov/pubmed/27074145 http://dx.doi.org/10.1371/journal.pcbi.1004870 |