White Matter Microstructural Organization Is Higher with Age in Adult Superior Cerebellar Peduncles

Using diffusion tensor imaging, we conducted an exploratory investigation of the relationship between white matter tract microstructure and age in 200 healthy adult subjects using tract-based spatial statistics (TBSS). Though most tracts showed the slight decline in microstructural organization with...

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Autores principales: Kanaan, Richard A., Allin, Matthew, Picchioni, Marco M., Shergill, Sukhwinder S., McGuire, Philip K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830843/
https://www.ncbi.nlm.nih.gov/pubmed/27148043
http://dx.doi.org/10.3389/fnagi.2016.00071
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author Kanaan, Richard A.
Allin, Matthew
Picchioni, Marco M.
Shergill, Sukhwinder S.
McGuire, Philip K.
author_facet Kanaan, Richard A.
Allin, Matthew
Picchioni, Marco M.
Shergill, Sukhwinder S.
McGuire, Philip K.
author_sort Kanaan, Richard A.
collection PubMed
description Using diffusion tensor imaging, we conducted an exploratory investigation of the relationship between white matter tract microstructure and age in 200 healthy adult subjects using tract-based spatial statistics (TBSS). Though most tracts showed the slight decline in microstructural organization with age widely noted, in both superior cerebellar peduncles (SCP) it correlated positively with age, a result not previously reported. We confirmed this by using an alternative method, and by repeating our TBSS analysis in an additional sample of 133 healthy adults. In exploring this surprising result we considered the possibility that this might arise from the continual cognitive and motor refinement that is enacted in the cerebellum: we found that tract microstructure in both SCPs was also strongly correlated with IQ, again in contrast with all other tracts, and its relationship with age mediated by IQ, as a training model would predict.
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spelling pubmed-48308432016-05-04 White Matter Microstructural Organization Is Higher with Age in Adult Superior Cerebellar Peduncles Kanaan, Richard A. Allin, Matthew Picchioni, Marco M. Shergill, Sukhwinder S. McGuire, Philip K. Front Aging Neurosci Neuroscience Using diffusion tensor imaging, we conducted an exploratory investigation of the relationship between white matter tract microstructure and age in 200 healthy adult subjects using tract-based spatial statistics (TBSS). Though most tracts showed the slight decline in microstructural organization with age widely noted, in both superior cerebellar peduncles (SCP) it correlated positively with age, a result not previously reported. We confirmed this by using an alternative method, and by repeating our TBSS analysis in an additional sample of 133 healthy adults. In exploring this surprising result we considered the possibility that this might arise from the continual cognitive and motor refinement that is enacted in the cerebellum: we found that tract microstructure in both SCPs was also strongly correlated with IQ, again in contrast with all other tracts, and its relationship with age mediated by IQ, as a training model would predict. Frontiers Media S.A. 2016-04-14 /pmc/articles/PMC4830843/ /pubmed/27148043 http://dx.doi.org/10.3389/fnagi.2016.00071 Text en Copyright © 2016 Kanaan, Allin, Picchioni, Shergill and McGuire. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Kanaan, Richard A.
Allin, Matthew
Picchioni, Marco M.
Shergill, Sukhwinder S.
McGuire, Philip K.
White Matter Microstructural Organization Is Higher with Age in Adult Superior Cerebellar Peduncles
title White Matter Microstructural Organization Is Higher with Age in Adult Superior Cerebellar Peduncles
title_full White Matter Microstructural Organization Is Higher with Age in Adult Superior Cerebellar Peduncles
title_fullStr White Matter Microstructural Organization Is Higher with Age in Adult Superior Cerebellar Peduncles
title_full_unstemmed White Matter Microstructural Organization Is Higher with Age in Adult Superior Cerebellar Peduncles
title_short White Matter Microstructural Organization Is Higher with Age in Adult Superior Cerebellar Peduncles
title_sort white matter microstructural organization is higher with age in adult superior cerebellar peduncles
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830843/
https://www.ncbi.nlm.nih.gov/pubmed/27148043
http://dx.doi.org/10.3389/fnagi.2016.00071
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