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Metabolically inert perfluorinated fatty acids directly activate uncoupling protein 1 in brown-fat mitochondria
The metabolically inert perfluorinated fatty acids perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) can display fatty acid-like activity in biological systems. The uncoupling protein 1 (UCP1) in brown adipose tissue is physiologically (re)activated by fatty acids, including octanoate....
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830884/ https://www.ncbi.nlm.nih.gov/pubmed/26041126 http://dx.doi.org/10.1007/s00204-015-1535-4 |