Cargando…

Structural insights and functional implications of inter-individual variability in β(2)-adrenergic receptor

The human β(2)-adrenergic receptor (β(2)AR) belongs to the G protein-coupled receptor (GPCR) family and due to its central role in bronchodilation, is an important drug target. The inter-individual variability in β(2)AR has been implicated in disease susceptibility and differential drug response. In...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tandale, Aditi, Joshi, Manali, Sengupta, Durba
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830965/ https://www.ncbi.nlm.nih.gov/pubmed/27075228 http://dx.doi.org/10.1038/srep24379

Ejemplares similares

Molecular Insights into the Dynamics of Pharmacogenetically Important N-Terminal Variants of the Human β(2)-Adrenergic Receptor
por: Shahane, Ganesh, et al.
Publicado: (2014)

Conformational plasticity and dynamic interactions of the N-terminal domain of the chemokine receptor CXCR1
por: Kharche, Shalmali, et al.
Publicado: (2021)

Conformational plasticity of ligand-bound and ternary GPCR complexes studied by (19)F NMR of the β(1)-adrenergic receptor
por: Frei, J. Niclas, et al.
Publicado: (2020)

New Insights into the Inter-Individual Variability in Perspective Taking
por: Bukowski, Henryk, et al.
Publicado: (2017)

β-adrenergic receptor responsiveness in aging heart and clinical implications
por: Ferrara, Nicola, et al.
Publicado: (2014)

COVID-19: Understanding Inter-Individual Variability and Implications for Precision Medicine
por: Pereira, Naveen L., et al.
Publicado: (2021)

Involvement of β-adrenergic receptor in synaptic vesicle swelling and implication in neurotransmitter release
por: Chen, Zhi Hui, et al.
Publicado: (2011)

Gi-protein-coupled β (1)-adrenergic receptor: re-understanding the selectivity of β (1)-adrenergic receptor to G protein : Gi-protein-coupled β (1)-adrenergic receptor
por: Chen, Hao, et al.
Publicado: (2022)

Heterodimerization of β(2 )adrenergic receptor and somatostatin receptor 5: Implications in modulation of signaling pathway
por: Somvanshi, Rishi K, et al.
Publicado: (2011)

Crystal Structure of the β(2)Adrenergic Receptor-Gs protein complex
por: Rasmussen, Søren G.F., et al.
Publicado: (2011)

Inter-Individual Variability in Xenobiotic-Metabolizing Enzymes: Implications for Human Aging and Longevity
por: Crocco, Paolina, et al.
Publicado: (2019)

Internalization Dissociates β(2)-Adrenergic Receptors
por: Lan, Tien-Hung, et al.
Publicado: (2011)

β-Adrenergic Receptor Signaling in Prostate Cancer
por: Braadland, Peder Rustøen, et al.
Publicado: (2015)

Optodynamic simulation of β-adrenergic receptor signalling
por: Siuda, Edward R., et al.
Publicado: (2015)

β-Adrenergic Receptor and Insulin Resistance in the Heart
por: Mangmool, Supachoke, et al.
Publicado: (2017)

β2-Adrenergic Receptor Mediated Inhibition of T Cell Function and Its Implications for CAR-T Cell Therapy
por: Farooq, Muhammad Asad, et al.
Publicado: (2023)

Muscle Plasticity and β(2)-Adrenergic Receptors: Adaptive Responses of β(2)-Adrenergic Receptor Expression to Muscle Hypertrophy and Atrophy
por: Sato, Shogo, et al.
Publicado: (2011)

Phosphodiesterase 4D disruption causes β2 adrenergic receptors to behave like β1 adrenergic receptors in vivo
por: Pearl, N, et al.
Publicado: (2006)

β-Adrenergic receptor signaling in cardiac function and heart failure
por: Madamanchi, Aasakiran
Publicado: (2007)

Structures of β(1)-adrenergic receptor in complex with Gs and ligands of different efficacies
por: Su, Minfei, et al.
Publicado: (2022)

A Review of Factors Affecting Anthocyanin Bioavailability: Possible Implications for the Inter-Individual Variability
por: Eker, Merve Eda, et al.
Publicado: (2019)

Cardiac physiologic regulation of sub-type specific adrenergic receptors in transgenic mice overexpressing β(1)- and β(2)-adrenergic receptors
por: Kim, Ka Eul, et al.
Publicado: (2016)

Characterization of β-adrenergic receptors in bovine intramuscular and subcutaneous adipose tissue: comparison of lubabegron fumarate with β-adrenergic receptor agonists and antagonists
por: Hwang, Jinhee H, et al.
Publicado: (2021)

Structural insights into ligand recognition, activation, and signaling of the α(2A) adrenergic receptor
por: Xu, Jun, et al.
Publicado: (2022)

Inter-individual Differences in Heart Rate Variability Are Associated with Inter-individual Differences in Empathy and Alexithymia
por: Lischke, Alexander, et al.
Publicado: (2018)

Inter-individual differences in heart rate variability are associated with inter-individual differences in mind-reading
por: Lischke, Alexander, et al.
Publicado: (2017)

Inter occasion variability in individual optimal design
por: Kristoffersson, Anders N., et al.
Publicado: (2015)

Molecular Basis of Ligand Dissociation in β-Adrenergic Receptors
por: González, Angel, et al.
Publicado: (2011)

Agonist-Directed Desensitization of the β(2)-Adrenergic Receptor
por: Goral, Vasiliy, et al.
Publicado: (2011)

On Variability and Genes: Inter-individual Differences in Auditory Brain Function
por: Sörös, Peter, et al.
Publicado: (2012)

The structural basis for agonist and partial agonist action on a β(1)-adrenergic receptor
por: Warne, Tony, et al.
Publicado: (2011)

β2-adrenergic receptor gene polymorphisms in normal and asthmatic individuals in the Eastern Province of Saudi Arabia
por: Al-Rubaish, Abdullah
Publicado: (2011)

Functional Characterization of the Obesity-Linked Variant of the β(3)-Adrenergic Receptor
por: Haji, Esraa, et al.
Publicado: (2021)

Prolonged β-adrenergic stimulation disperses ryanodine receptor clusters in cardiomyocytes and has implications for heart failure
por: Shen, Xin, et al.
Publicado: (2022)

3D Structure Prediction of Human β1-Adrenergic Receptor via Threading-Based Homology Modeling for Implications in Structure-Based Drug Designing
por: Ul-Haq, Zaheer, et al.
Publicado: (2015)

Linking Inter-Individual Variability in Functional Brain Connectivity to Cognitive Ability in Elderly Individuals
por: Li, Rui, et al.
Publicado: (2017)

Inter-individual cognitive variability in children with Asperger's syndrome
por: Gonzalez-Gadea, Maria Luz, et al.
Publicado: (2014)

Inter- and intra-individual variability in alpha peak frequency
por: Haegens, Saskia, et al.
Publicado: (2014)

Inter-individual variability in the foraging behaviour of traplining bumblebees
por: Klein, Simon, et al.
Publicado: (2017)

Understanding Inter-Individual Variability in Monoclonal Antibody Disposition
por: Thomas, Veena A., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_0156sg9sb0si5inejpvr4kc5ld