Discovery of a specific inhibitor of human GLUT5 by virtual screening and in vitro transport evaluation

GLUT5, a fructose-transporting member of the facilitative glucose transporter (GLUT, SLC2) family, is a therapeutic target for diabetes and cancer but has no potent inhibitors. We virtually screened a library of 6 million chemicals onto a GLUT5 model and identified N-[4-(methylsulfonyl)-2-nitropheny...

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Detalles Bibliográficos
Autores principales: George Thompson, Alayna M., Ursu, Oleg, Babkin, Petr, Iancu, Cristina V., Whang, Alex, Oprea, Tudor I., Choe, Jun-yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831007/
https://www.ncbi.nlm.nih.gov/pubmed/27074918
http://dx.doi.org/10.1038/srep24240

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831007/
https://www.ncbi.nlm.nih.gov/pubmed/27074918
http://dx.doi.org/10.1038/srep24240

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