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Discovery of a specific inhibitor of human GLUT5 by virtual screening and in vitro transport evaluation

GLUT5, a fructose-transporting member of the facilitative glucose transporter (GLUT, SLC2) family, is a therapeutic target for diabetes and cancer but has no potent inhibitors. We virtually screened a library of 6 million chemicals onto a GLUT5 model and identified N-[4-(methylsulfonyl)-2-nitropheny...

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Detalles Bibliográficos
Autores principales:	George Thompson, Alayna M., Ursu, Oleg, Babkin, Petr, Iancu, Cristina V., Whang, Alex, Oprea, Tudor I., Choe, Jun-yong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831007/ https://www.ncbi.nlm.nih.gov/pubmed/27074918 http://dx.doi.org/10.1038/srep24240

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