A programmable synthetic lineage-control network that differentiates human IPSCs into glucose-sensitive insulin-secreting beta-like cells

Synthetic biology has advanced the design of standardized transcription control devices that programme cellular behaviour. By coupling synthetic signalling cascade- and transcription factor-based gene switches with reverse and differential sensitivity to the licensed food additive vanillic acid, we...

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Detalles Bibliográficos
Autores principales: Saxena, Pratik, Heng, Boon Chin, Bai, Peng, Folcher, Marc, Zulewski, Henryk, Fussenegger, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831023/
https://www.ncbi.nlm.nih.gov/pubmed/27063289
http://dx.doi.org/10.1038/ncomms11247

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831023/
https://www.ncbi.nlm.nih.gov/pubmed/27063289
http://dx.doi.org/10.1038/ncomms11247

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