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Probing the mechanism of cardiovascular drugs using a covalent levosimendan analog
One approach to improve contraction in the failing heart is the administration of calcium (Ca(2 +)) sensitizers. Although it is known that levosimendan and other sensitizers bind to troponin C (cTnC), their in vivo mechanism is not fully understood. Based on levosimendan, we designed a covalent Ca(2...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Academic Press
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831045/ https://www.ncbi.nlm.nih.gov/pubmed/26853943 http://dx.doi.org/10.1016/j.yjmcc.2016.02.003 |