Single-cell profiling of lncRNAs in the developing human brain

Single-cell RNA-seq in samples from the human neocortex demonstrate that long noncoding RNAs (lncRNAs) are abundantly expressed in specific individual brain cells, despite being hard to detect in bulk samples. This result suggests that the lncRNAs might have important functions in specific cell type...

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Detalles Bibliográficos
Autores principales: Ma, Qing, Chang, Howard Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Highlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831122/
https://www.ncbi.nlm.nih.gov/pubmed/27079200
http://dx.doi.org/10.1186/s13059-016-0933-0
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author Ma, Qing
Chang, Howard Y.
author_facet Ma, Qing
Chang, Howard Y.
author_sort Ma, Qing
collection PubMed
description Single-cell RNA-seq in samples from the human neocortex demonstrate that long noncoding RNAs (lncRNAs) are abundantly expressed in specific individual brain cells, despite being hard to detect in bulk samples. This result suggests that the lncRNAs might have important functions in specific cell types in the brain. Please see related Research article: www.dx.doi.org/10.1186/s13059-016-0932-1
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spelling pubmed-48311222016-04-15 Single-cell profiling of lncRNAs in the developing human brain Ma, Qing Chang, Howard Y. Genome Biol Research Highlight Single-cell RNA-seq in samples from the human neocortex demonstrate that long noncoding RNAs (lncRNAs) are abundantly expressed in specific individual brain cells, despite being hard to detect in bulk samples. This result suggests that the lncRNAs might have important functions in specific cell types in the brain. Please see related Research article: www.dx.doi.org/10.1186/s13059-016-0932-1 BioMed Central 2016-04-14 /pmc/articles/PMC4831122/ /pubmed/27079200 http://dx.doi.org/10.1186/s13059-016-0933-0 Text en © Ma and Chang. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Highlight
Ma, Qing
Chang, Howard Y.
Single-cell profiling of lncRNAs in the developing human brain
title Single-cell profiling of lncRNAs in the developing human brain
title_full Single-cell profiling of lncRNAs in the developing human brain
title_fullStr Single-cell profiling of lncRNAs in the developing human brain
title_full_unstemmed Single-cell profiling of lncRNAs in the developing human brain
title_short Single-cell profiling of lncRNAs in the developing human brain
title_sort single-cell profiling of lncrnas in the developing human brain
topic Research Highlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831122/
https://www.ncbi.nlm.nih.gov/pubmed/27079200
http://dx.doi.org/10.1186/s13059-016-0933-0
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