The Intracellular Loop 2 F328S Frizzled-4 Mutation Implicated in Familial Exudative Vitreoretinopathy Impairs Dishevelled Recruitment

Familial exudative vitreoretinopathy (FEVR) is a disease state characterized by aberrant retinal angiogenesis. Norrin-induced activation of Frizzled-4 (Fz4) has a major role in regulating beta-catenin levels in the eye that, in turn, modulate the blood retina barrier (BRB). Here we gain insight on t...

Descripción completa

Detalles Bibliográficos
Autores principales: Pau, Milly S., Gao, Shujuan, Malbon, Craig C., Wang, Hsien-yu, Bertalovitz, Alexander C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ubiquity Press 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831297/
https://www.ncbi.nlm.nih.gov/pubmed/27096003
http://dx.doi.org/10.5334/1750-2187-10-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831297/
https://www.ncbi.nlm.nih.gov/pubmed/27096003
http://dx.doi.org/10.5334/1750-2187-10-6

Ejemplares similares