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The Intracellular Loop 2 F328S Frizzled-4 Mutation Implicated in Familial Exudative Vitreoretinopathy Impairs Dishevelled Recruitment

Familial exudative vitreoretinopathy (FEVR) is a disease state characterized by aberrant retinal angiogenesis. Norrin-induced activation of Frizzled-4 (Fz4) has a major role in regulating beta-catenin levels in the eye that, in turn, modulate the blood retina barrier (BRB). Here we gain insight on t...

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Detalles Bibliográficos
Autores principales:	Pau, Milly S., Gao, Shujuan, Malbon, Craig C., Wang, Hsien-yu, Bertalovitz, Alexander C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ubiquity Press 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831297/ https://www.ncbi.nlm.nih.gov/pubmed/27096003 http://dx.doi.org/10.5334/1750-2187-10-6

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