Insulator dysfunction and oncogene activation in IDH mutant gliomas

Gain-of-function IDH mutations are initiating events that define major clinical and prognostic classes of gliomas(1,2). Mutant IDH protein produces a novel onco-metabolite, 2-hydroxyglutarate (2-HG), that interferes with iron-dependent hydroxylases, including the TET family of 5′-methylcytosine hydr...

Descripción completa

Detalles Bibliográficos
Autores principales: Flavahan, William A., Drier, Yotam, Liau, Brian B., Gillespie, Shawn M., Venteicher, Andrew S., Stemmer-Rachamimov, Anat O., Suvà, Mario L., Bernstein, Bradley E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831574/
https://www.ncbi.nlm.nih.gov/pubmed/26700815
http://dx.doi.org/10.1038/nature16490

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831574/
https://www.ncbi.nlm.nih.gov/pubmed/26700815
http://dx.doi.org/10.1038/nature16490

Ejemplares similares