Hypoxia Induces Autophagy through Translational Up-Regulation of Lysosomal Proteins in Human Colon Cancer Cells

Hypoxia occurs in a wide variety of physiological and pathological conditions, including tumorigenesis. Tumor cells have to adapt to hypoxia by altering their gene expression and protein synthesis. Here, we showed that hypoxia inhibits translation through activation of PERK and inactivation of mTOR...

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Detalles Bibliográficos
Autores principales: Lai, Ming-Chih, Chang, Chiao-May, Sun, H. Sunny
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831676/
https://www.ncbi.nlm.nih.gov/pubmed/27078027
http://dx.doi.org/10.1371/journal.pone.0153627

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831676/
https://www.ncbi.nlm.nih.gov/pubmed/27078027
http://dx.doi.org/10.1371/journal.pone.0153627

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