Inhibition of the JAK/STAT Signaling Pathway in Regulatory T Cells Reveals a Very Dynamic Regulation of Foxp3 Expression

The IL-2/JAK3/STAT-5 signaling pathway is involved on the initiation and maintenance of the transcription factor Foxp3 in regulatory T cells (Treg) and has been associated with demethylation of the intronic Conserved Non Coding Sequence-2 (CNS2). However, the role of the JAK/STAT pathway in controll...

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Detalles Bibliográficos
Autores principales: Goldstein, Jérémie D., Burlion, Aude, Zaragoza, Bruno, Sendeyo, Kélhia, Polansky, Julia K., Huehn, Jochen, Piaggio, Eliane, Salomon, Benoit L., Marodon, Gilles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831811/
https://www.ncbi.nlm.nih.gov/pubmed/27077371
http://dx.doi.org/10.1371/journal.pone.0153682

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831811/
https://www.ncbi.nlm.nih.gov/pubmed/27077371
http://dx.doi.org/10.1371/journal.pone.0153682

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