DNA‐damage response gene GADD45A induces differentiation in hematopoietic stem cells without inhibiting cell cycle or survival

Hematopoietic stem cells (HSCs) maintain blood cell production life‐long by their unique abilities of self‐renewal and differentiation into all blood cell lineages. Growth arrest and DNA‐damage‐inducible 45 alpha (GADD45A) is induced by genotoxic stress in HSCs. GADD45A has been implicated in cell c...

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Detalles Bibliográficos
Autores principales: Wingert, Susanne, Thalheimer, Frederic B., Haetscher, Nadine, Rehage, Maike, Schroeder, Timm, Rieger, Michael A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Tissue‐Specific Stem Cells
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832267/
https://www.ncbi.nlm.nih.gov/pubmed/26731607
http://dx.doi.org/10.1002/stem.2282

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832267/
https://www.ncbi.nlm.nih.gov/pubmed/26731607
http://dx.doi.org/10.1002/stem.2282

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