Metabolic activation of 2‐amino‐1‐methyl‐6‐phenylimidazo [4,5‐b]pyridine and DNA adduct formation depends on p53: Studies in T rp53(+/+),T rp53(+/−) and T rp53(−/−) mice

The expression of the tumor suppressor p53 can influence the bioactivation of, and DNA damage induced by, the environmental carcinogen benzo[a]pyrene, indicating a role for p53 in its cytochrome P450 (CYP)‐mediated biotransformation. The carcinogen 2‐amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine (Ph...

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Detalles Bibliográficos
Autores principales: Krais, Annette M., Speksnijder, Ewoud N., Melis, Joost P.M., Singh, Rajinder, Caldwell, Anna, Gamboa da Costa, Gonçalo, Luijten, Mirjam, Phillips, David H., Arlt, Volker M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Molecular Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832306/
https://www.ncbi.nlm.nih.gov/pubmed/26335255
http://dx.doi.org/10.1002/ijc.29836

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832306/
https://www.ncbi.nlm.nih.gov/pubmed/26335255
http://dx.doi.org/10.1002/ijc.29836

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