Easy To Synthesize, Robust Organo‐osmium Asymmetric Transfer Hydrogenation Catalysts

Asymmetric transfer hydrogenation (ATH) is an important process in organic synthesis for which the Noyori‐type Ru(II) catalysts [(arene)Ru(Tsdiamine)] are now well established and widely used. We now demonstrate for the first time the catalytic activity of the osmium analogues. X‐ray crystal structu...

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Detalles Bibliográficos
Autores principales: Coverdale, James P. C., Sanchez‐Cano, Carlos, Clarkson, Guy J., Soni, Rina, Wills, Martin, Sadler, Peter J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY‐VCH Verlag 2015
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832837/
https://www.ncbi.nlm.nih.gov/pubmed/25853228
http://dx.doi.org/10.1002/chem.201500534
Descripción
Sumario:Asymmetric transfer hydrogenation (ATH) is an important process in organic synthesis for which the Noyori‐type Ru(II) catalysts [(arene)Ru(Tsdiamine)] are now well established and widely used. We now demonstrate for the first time the catalytic activity of the osmium analogues. X‐ray crystal structures of the 16‐electron Os(II) catalysts are almost identical to those of Ru(II). Intriguingly the precursor complex was isolated as a dichlorido complex with a monodentate amine ligand. The Os(II) catalysts are readily synthesised (within 1 h) and exhibit excellent enantioselectivity in ATH reactions of ketones.

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