Easy To Synthesize, Robust Organo‐osmium Asymmetric Transfer Hydrogenation Catalysts

Asymmetric transfer hydrogenation (ATH) is an important process in organic synthesis for which the Noyori‐type Ru(II) catalysts [(arene)Ru(Tsdiamine)] are now well established and widely used. We now demonstrate for the first time the catalytic activity of the osmium analogues. X‐ray crystal structu...

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Detalles Bibliográficos
Autores principales: Coverdale, James P. C., Sanchez‐Cano, Carlos, Clarkson, Guy J., Soni, Rina, Wills, Martin, Sadler, Peter J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY‐VCH Verlag 2015
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832837/
https://www.ncbi.nlm.nih.gov/pubmed/25853228
http://dx.doi.org/10.1002/chem.201500534
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author Coverdale, James P. C.
Sanchez‐Cano, Carlos
Clarkson, Guy J.
Soni, Rina
Wills, Martin
Sadler, Peter J.
author_facet Coverdale, James P. C.
Sanchez‐Cano, Carlos
Clarkson, Guy J.
Soni, Rina
Wills, Martin
Sadler, Peter J.
author_sort Coverdale, James P. C.
collection PubMed
description Asymmetric transfer hydrogenation (ATH) is an important process in organic synthesis for which the Noyori‐type Ru(II) catalysts [(arene)Ru(Tsdiamine)] are now well established and widely used. We now demonstrate for the first time the catalytic activity of the osmium analogues. X‐ray crystal structures of the 16‐electron Os(II) catalysts are almost identical to those of Ru(II). Intriguingly the precursor complex was isolated as a dichlorido complex with a monodentate amine ligand. The Os(II) catalysts are readily synthesised (within 1 h) and exhibit excellent enantioselectivity in ATH reactions of ketones.
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spelling pubmed-48328372016-04-27 Easy To Synthesize, Robust Organo‐osmium Asymmetric Transfer Hydrogenation Catalysts Coverdale, James P. C. Sanchez‐Cano, Carlos Clarkson, Guy J. Soni, Rina Wills, Martin Sadler, Peter J. Chemistry Communications Asymmetric transfer hydrogenation (ATH) is an important process in organic synthesis for which the Noyori‐type Ru(II) catalysts [(arene)Ru(Tsdiamine)] are now well established and widely used. We now demonstrate for the first time the catalytic activity of the osmium analogues. X‐ray crystal structures of the 16‐electron Os(II) catalysts are almost identical to those of Ru(II). Intriguingly the precursor complex was isolated as a dichlorido complex with a monodentate amine ligand. The Os(II) catalysts are readily synthesised (within 1 h) and exhibit excellent enantioselectivity in ATH reactions of ketones. WILEY‐VCH Verlag 2015-04-08 2015-05-26 /pmc/articles/PMC4832837/ /pubmed/25853228 http://dx.doi.org/10.1002/chem.201500534 Text en © 2015 The Authors. Published by Wiley‐VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. Open access.
spellingShingle Communications
Coverdale, James P. C.
Sanchez‐Cano, Carlos
Clarkson, Guy J.
Soni, Rina
Wills, Martin
Sadler, Peter J.
Easy To Synthesize, Robust Organo‐osmium Asymmetric Transfer Hydrogenation Catalysts
title Easy To Synthesize, Robust Organo‐osmium Asymmetric Transfer Hydrogenation Catalysts
title_full Easy To Synthesize, Robust Organo‐osmium Asymmetric Transfer Hydrogenation Catalysts
title_fullStr Easy To Synthesize, Robust Organo‐osmium Asymmetric Transfer Hydrogenation Catalysts
title_full_unstemmed Easy To Synthesize, Robust Organo‐osmium Asymmetric Transfer Hydrogenation Catalysts
title_short Easy To Synthesize, Robust Organo‐osmium Asymmetric Transfer Hydrogenation Catalysts
title_sort easy to synthesize, robust organo‐osmium asymmetric transfer hydrogenation catalysts
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832837/
https://www.ncbi.nlm.nih.gov/pubmed/25853228
http://dx.doi.org/10.1002/chem.201500534
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