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Calpain Inhibitor Reduces Cancer-induced Bone Pain Possibly Through Inhibition of Osteoclastogenesis in Rat Cancer-induced Bone Pain Model

BACKGROUND: Calpain, a calcium-dependent cysteine protease, has been demonstrated to regulate osteoclastogenesis, which is considered one of the major reasons for cancer-induced bone pain (CIBP). In the present study, calpain inhibitor was applied in a rat CIBP model to determine whether it could re...

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Detalles Bibliográficos
Autores principales: Xu, Jia-Ying, Jiang, Yu, Liu, Wei, Huang, Yu-Guang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832953/
https://www.ncbi.nlm.nih.gov/pubmed/25881607
http://dx.doi.org/10.4103/0366-6999.155109