Quantitative proteomic analysis reveals maturation as a mechanism underlying glucocorticoid resistance in B lineage ALL and re‐sensitization by JNK inhibition

Glucocorticoid (GC) resistance is a continuing clinical problem in childhood acute lymphoblastic leukaemia (ALL) but the underlying mechanisms remain unclear. A proteomic approach was used to compare profiles of the B‐lineage ALL GC‐sensitive cell line, PreB 697, and its GC‐resistant sub‐line, R3F9,...

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Detalles Bibliográficos
Autores principales: Nicholson, Lindsay, Evans, Caroline A., Matheson, Elizabeth, Minto, Lynne, Keilty, Christopher, Sanichar, Maryna, Case, Marian, Schwab, Claire, Williamson, Daniel, Rainer, Johannes, Harrison, Christine J., Kofler, Reinhard, Hall, Andrew G., Redfern, Christopher P. F., Whetton, Anthony D., Irving, Julie A. E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Paediatrics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833193/
https://www.ncbi.nlm.nih.gov/pubmed/26310606
http://dx.doi.org/10.1111/bjh.13647

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833193/
https://www.ncbi.nlm.nih.gov/pubmed/26310606
http://dx.doi.org/10.1111/bjh.13647

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