HTLV-1 Tax Functions as a Ubiquitin E3 Ligase for Direct IKK Activation via Synthesis of Mixed-Linkage Polyubiquitin Chains

The HTLV-1 oncoprotein Tax plays a key role in CD4(+) T cell transformation by promoting cell proliferation and survival, mainly through permanent activation of the NK-κB pathway and induction of many NF-κB target genes. Elucidating the underlying molecular mechanism is therefore critical in underst...

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Detalles Bibliográficos
Autores principales: Wang, Chong, Long, Wenying, Peng, Chao, Hu, Lin, Zhang, Qiong, Wu, Ailing, Zhang, Xiaoqing, Duan, Xiaotao, Wong, Catherine C. L., Tanaka, Yuetsu, Xia, Zongping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833305/
https://www.ncbi.nlm.nih.gov/pubmed/27082114
http://dx.doi.org/10.1371/journal.ppat.1005584

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833305/
https://www.ncbi.nlm.nih.gov/pubmed/27082114
http://dx.doi.org/10.1371/journal.ppat.1005584

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