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Nonlinear Dynamics in Gene Regulation Promote Robustness and Evolvability of Gene Expression Levels
Cellular phenotypes underpinned by regulatory networks need to respond to evolutionary pressures to allow adaptation, but at the same time be robust to perturbations. This creates a conflict in which mutations affecting regulatory networks must both generate variance but also be tolerated at the phe...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833316/ https://www.ncbi.nlm.nih.gov/pubmed/27082741 http://dx.doi.org/10.1371/journal.pone.0153295 |