Assessing a peptidylic inhibitor-based therapeutic approach that simultaneously suppresses polyglutamine RNA- and protein-mediated toxicities in patient cells and Drosophila

Polyglutamine (polyQ) diseases represent a group of progressive neurodegenerative disorders that are caused by abnormal expansion of CAG triplet nucleotides in disease genes. Recent evidence indicates that not only mutant polyQ proteins, but also their corresponding mutant RNAs, contribute to the pa...

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Detalles Bibliográficos
Autores principales: Zhang, Qian, Tsoi, Ho, Peng, Shaohong, Li, Pan P., Lau, Kwok-Fai, Rudnicki, Dobrila D., Ngo, Jacky Chi-Ki, Chan, Ho Yin Edwin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833327/
https://www.ncbi.nlm.nih.gov/pubmed/26839389
http://dx.doi.org/10.1242/dmm.022350

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833327/
https://www.ncbi.nlm.nih.gov/pubmed/26839389
http://dx.doi.org/10.1242/dmm.022350

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