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Tau excess impairs mitosis and kinesin-5 function, leading to aneuploidy and cell death

In neurodegenerative diseases such as Alzheimer's disease (AD), cell cycle defects and associated aneuploidy have been described. However, the importance of these defects in the physiopathology of AD and the underlying mechanistic processes are largely unknown, in particular with respect to the...

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Detalles Bibliográficos
Autores principales: Bougé, Anne-Laure, Parmentier, Marie-Laure
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833329/
https://www.ncbi.nlm.nih.gov/pubmed/26822478
http://dx.doi.org/10.1242/dmm.022558