Cargando…
Tau excess impairs mitosis and kinesin-5 function, leading to aneuploidy and cell death
In neurodegenerative diseases such as Alzheimer's disease (AD), cell cycle defects and associated aneuploidy have been described. However, the importance of these defects in the physiopathology of AD and the underlying mechanistic processes are largely unknown, in particular with respect to the...
Autores principales: | Bougé, Anne-Laure, Parmentier, Marie-Laure |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Company of Biologists Ltd
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833329/ https://www.ncbi.nlm.nih.gov/pubmed/26822478 http://dx.doi.org/10.1242/dmm.022558 |
Ejemplares similares
-
Loss of kinesin-14 results in aneuploidy via kinesin-5-dependent microtubule protrusions leading to chromosome cut
por: Syrovatkina, Viktoriya, et al.
Publicado: (2015) -
The Molecular Basis for Kinesin Functional Specificity During Mitosis
por: Welburn, Julie P I
Publicado: (2013) -
Kinesin-2 Controls the Motility of RAB5 Endosomes and Their Association with the Spindle in Mitosis
por: Pupo, Emanuela, et al.
Publicado: (2018) -
Vesicular Axonal Transport is Modified In Vivo by Tau Deletion or Overexpression in Drosophila
por: Talmat-Amar, Yasmina, et al.
Publicado: (2018) -
The kinesin-like protein KLP61F is essential for mitosis in Drosophila
Publicado: (1993)