Cardiomyocyte-specific conditional knockout of the histone chaperone HIRA in mice results in hypertrophy, sarcolemmal damage and focal replacement fibrosis

HIRA is the histone chaperone responsible for replication-independent incorporation of histone variant H3.3 within gene bodies and regulatory regions of actively transcribed genes, and within the bivalent promoter regions of developmentally regulated genes. The HIRA gene lies within the 22q11.2 dele...

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Detalles Bibliográficos
Autores principales: Valenzuela, Nicolas, Fan, Qiying, Fa'ak, Faisal, Soibam, Benjamin, Nagandla, Harika, Liu, Yu, Schwartz, Robert J., McConnell, Bradley K., Stewart, M. David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833330/
https://www.ncbi.nlm.nih.gov/pubmed/26935106
http://dx.doi.org/10.1242/dmm.022889

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833330/
https://www.ncbi.nlm.nih.gov/pubmed/26935106
http://dx.doi.org/10.1242/dmm.022889

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