OTSSP167 Abrogates Mitotic Checkpoint through Inhibiting Multiple Mitotic Kinases

OTSSP167 was recently characterized as a potent inhibitor for maternal embryonic leucine zipper kinase (MELK) and is currently tested in Phase I clinical trials for solid tumors that have not responded to other treatment. Here we report that OTSSP167 abrogates the mitotic checkpoint at concentration...

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Detalles Bibliográficos
Autores principales: Ji, Wenbin, Arnst, Christopher, Tipton, Aaron R., Bekier, Michael E., Taylor, William R., Yen, Tim J., Liu, Song-Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833387/
https://www.ncbi.nlm.nih.gov/pubmed/27082996
http://dx.doi.org/10.1371/journal.pone.0153518

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833387/
https://www.ncbi.nlm.nih.gov/pubmed/27082996
http://dx.doi.org/10.1371/journal.pone.0153518

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