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OTSSP167 Abrogates Mitotic Checkpoint through Inhibiting Multiple Mitotic Kinases

OTSSP167 was recently characterized as a potent inhibitor for maternal embryonic leucine zipper kinase (MELK) and is currently tested in Phase I clinical trials for solid tumors that have not responded to other treatment. Here we report that OTSSP167 abrogates the mitotic checkpoint at concentration...

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Detalles Bibliográficos
Autores principales:	Ji, Wenbin, Arnst, Christopher, Tipton, Aaron R., Bekier, Michael E., Taylor, William R., Yen, Tim J., Liu, Song-Tao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833387/ https://www.ncbi.nlm.nih.gov/pubmed/27082996 http://dx.doi.org/10.1371/journal.pone.0153518

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