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Nineteen-Step Total Synthesis of (+)-Phorbol

Phorbol, the flagship member of the tigliane diterpene family, has been known for over 80 years and has attracted attention from scores of chemists and biologists due to its intriguing chemical structure and the medicinal potential of phorbol esters.(1) Access to useful quantities of phorbol and rel...

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Detalles Bibliográficos
Autores principales: Kawamura, Shuhei, Chu, Hang, Felding, Jakob, Baran, Phil S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833603/
https://www.ncbi.nlm.nih.gov/pubmed/27007853
http://dx.doi.org/10.1038/nature17153