Structural insights of a PI3K/mTOR dual inhibitor with the morpholino-triazine scaffold

Stimulation of the PI3K/Akt/mTOR pathway, which controls cell proliferation and growth, is often observed in cancer cell. Inhibiting both PI3K and mTOR in this pathway can switch off Akt activation and hence, plays a powerful role for modulating this pathway. PKI-587, a drug containing the structure...

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Detalles Bibliográficos
Autores principales: Takeda, Takako, Wang, Yanli, Bryant, Stephen H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833818/
https://www.ncbi.nlm.nih.gov/pubmed/26956874
http://dx.doi.org/10.1007/s10822-016-9905-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833818/
https://www.ncbi.nlm.nih.gov/pubmed/26956874
http://dx.doi.org/10.1007/s10822-016-9905-4

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