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Phosphorylation modifies the molecular stability of β-amyloid deposits

Protein aggregation plays a crucial role in neurodegenerative diseases. A key feature of protein aggregates is their ubiquitous modification by phosphorylation. Little is known, however, about the molecular consequences of phosphorylation of protein aggregates. Here we show that phosphorylation of β...

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Detalles Bibliográficos
Autores principales: Rezaei-Ghaleh, Nasrollah, Amininasab, Mehriar, Kumar, Sathish, Walter, Jochen, Zweckstetter, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833870/
https://www.ncbi.nlm.nih.gov/pubmed/27072999
http://dx.doi.org/10.1038/ncomms11359