Cargando…

Short-term culture of tumour slices reveals the heterogeneous sensitivity of human head and neck squamous cell carcinoma to targeted therapies

BACKGROUND: Despite recent progress, investigating the impact of targeted therapies on Head and Neck Squamous Cell Carcinoma (HNSCC) remains a challenge. We investigated whether short-term culture of tumour fragments would permit the evaluation of tumour sensitivity to targeted therapies at the indi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Donnadieu, Jérôme, Lachaier, Emma, Peria, Marine, Saidak, Zuzana, Dakpe, Stéphanie, Ikoli, Jean-Fortune, Chauffert, Bruno, Page, Cyril, Galmiche, Antoine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834185/ https://www.ncbi.nlm.nih.gov/pubmed/27085492 http://dx.doi.org/10.1186/s12885-016-2318-x

Ejemplares similares

DNA damage response- and JAK-dependent regulation of PD-L1 expression in head and neck squamous cell carcinoma (HNSCC) cells exposed to 5-fluorouracil (5-FU)
por: Lailler, Claire, et al.
Publicado: (2021)

Evaluation of Proton MR Spectroscopy for the Study of the Tongue Tissue in Healthy Subjects and Patients With Tongue Squamous Cell Carcinoma: Preliminary Findings
por: Boussida, Salem, et al.
Publicado: (2022)

Contribution of Genomics to the Surgical Management and Study of Oral Cancer
por: Saidak, Zuzana, et al.
Publicado: (2021)

A pan-cancer study of the transcriptional regulation of uricogenesis in human tumours: pathological and pharmacological correlates
por: Saidak, Zuzana, et al.
Publicado: (2018)

Therapeutic Perspectives for the Perioperative Period in Oral Squamous Cell Carcinoma (OSCC)
por: Galmiche, Antoine, et al.
Publicado: (2022)

ERK1/2 signaling regulates the immune microenvironment and macrophage recruitment in glioblastoma
por: Lailler, Claire, et al.
Publicado: (2019)

Targeting coagulation to unlock antitumor immunity?
por: Galmiche, Antoine, et al.
Publicado: (2022)

Resensitization to Nivolumab after Intratumoral Chemotherapy in Recurrent Head and Neck Squamous Cell Cancer: A Report of 2 Cases
por: Houessinon, Aline, et al.
Publicado: (2020)

Combining genomic analyses with tumour-derived slice cultures for the characterization of an EGFR-activating kinase mutation in a case of glioblastoma
por: Loriguet, Lea, et al.
Publicado: (2018)

Molecular Landscape of the Coagulome of Oral Squamous Cell Carcinoma
por: Lottin, Marine, et al.
Publicado: (2022)

The Tumor Coagulome as a Transcriptional Target and a Potential Effector of Glucocorticoids in Human Cancers
por: Racine, Floriane, et al.
Publicado: (2023)

CD44, γ-H2AX, and p-ATM Expressions in Short-Term Ex Vivo Culture of Tumour Slices Predict the Treatment Response in Patients with Oral Squamous Cell Carcinoma
por: Philouze, Pierre, et al.
Publicado: (2022)

Metallothionein-1 as a biomarker of altered redox metabolism in hepatocellular carcinoma cells exposed to sorafenib
por: Houessinon, Aline, et al.
Publicado: (2016)

Thrombotic Microangiopathy Revealing Bone Metastases from an Ethmoid Sinus Carcinoma
por: Morisse, Mony Chenda, et al.
Publicado: (2016)

Editorial: Oral Oncology: From Precise Surgery to Precision Medicine and Surgery
por: Saidak, Zuzana, et al.
Publicado: (2022)

Protein biosynthesis, a target of sorafenib, interferes with the unfolded protein response (UPR) and ferroptosis in hepatocellular carcinoma cells
por: Sauzay, Chloé, et al.
Publicado: (2018)

Spectrum Slicing for Multiple Access Channels with Heterogeneous Services
por: Chiariotti, Federico, et al.
Publicado: (2021)

Heterogeneity of cancer-associated fibroblasts in head and neck squamous cell carcinoma
por: Mou, Tingchen, et al.
Publicado: (2023)

Ex vivo Imaging of T Cells in Murine Lymph Node Slices with Widefield and Confocal Microscopes
por: Salmon, Hélène, et al.
Publicado: (2011)

High Response Rate to Carboplatin-Paclitaxel-Cetuximab and Pembrolizumab in Patients with Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma
por: Chauffert, Bruno, et al.
Publicado: (2023)

Slice cultures from head and neck squamous cell carcinoma: a novel test system for drug susceptibility and mechanisms of resistance
por: Gerlach, M M, et al.
Publicado: (2014)

Spatial-linked alignment tool (SLAT) for aligning heterogenous slices
por: Xia, Chen-Rui, et al.
Publicado: (2023)

Epithelial-to-Mesenchymal Transition-Derived Heterogeneity in Head and Neck Squamous Cell Carcinomas
por: Baumeister, Philipp, et al.
Publicado: (2021)

Loss of HOP tumour suppressor expression in head and neck squamous cell carcinoma
por: Lemaire, F, et al.
Publicado: (2004)

Tumour-infiltrating lymphocytes in the risk stratification of squamous cell carcinoma of the head and neck
por: Jones, T M
Publicado: (2014)

Multi-Site Tumour Sampling Improves the Detection of Intra-Tumour Heterogeneity in Oral and Oropharyngeal Squamous Cell Carcinoma
por: Jie, Weiping, et al.
Publicado: (2021)

CCR7 ligands control basal T cell motility within lymph node slices in a phosphoinositide 3–kinase– independent manner
por: Asperti-Boursin, François, et al.
Publicado: (2007)

Ex Vivo Imaging of Resident CD8 T Lymphocytes in Human Lung Tumor Slices Using Confocal Microscopy
por: Peranzoni, Elisa, et al.
Publicado: (2017)

Tumour Genetic Heterogeneity in Relation to Oral Squamous Cell Carcinoma and Anti-Cancer Treatment
por: Feller, Gal, et al.
Publicado: (2023)

Heterogeneity of the Head and Neck Squamous Cell Carcinoma Immune Landscape and Its Impact on Immunotherapy
por: Canning, Madison, et al.
Publicado: (2019)

Intratumor heterogeneity of PD-L1 expression in head and neck squamous cell carcinoma
por: Rasmussen, Jacob H., et al.
Publicado: (2019)

Heterogeneity of cancer-associated fibroblasts in head and neck squamous cell carcinoma: opportunities and challenges
por: Hu, Chen, et al.
Publicado: (2023)

HPV, tumour metabolism and novel target identification in head and neck squamous cell carcinoma
por: Fleming, Jason C., et al.
Publicado: (2019)

Circulating tumour DNA alterations: emerging biomarker in head and neck squamous cell carcinoma
por: Huang, Xiaomin, et al.
Publicado: (2023)

Amiodarone is more efficient than verapamil in reversing resistance to anthracyclines in tumour cells.
por: Chauffert, B., et al.
Publicado: (1987)

Heterogeneity of Cancer Stem Cells in Tumorigenesis, Metastasis, and Resistance to Antineoplastic Treatment of Head and Neck Tumours
por: Cirillo, Nicola, et al.
Publicado: (2021)

Intraosseous microdialysis for bone free flap monitoring in head and neck reconstructive surgery: A prospective pilot study
por: Dakpé, Stéphanie, et al.
Publicado: (2019)

Profiling tumour heterogeneity through circulating tumour DNA in patients with pancreatic cancer
por: Adamo, Patricia, et al.
Publicado: (2017)

Cellular heterogeneity in tumours.
por: Woodruff, M. F.
Publicado: (1983)

Tumour Cell Heterogeneity
por: Gay, Laura, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_l2jgoke5j80n1kksdhis25d1lb