Conformational Selection and Induced Fit Mechanisms in the Binding of an Anticancer Drug to the c-Src Kinase

Understanding the conformational changes associated with the binding of small ligands to their biological targets is a fascinating and meaningful question in chemistry, biology and drug discovery. One of the most studied and important is the so-called “DFG-flip” of tyrosine kinases. The conserved th...

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Detalles Bibliográficos
Autores principales: Morando, Maria Agnese, Saladino, Giorgio, D’Amelio, Nicola, Pucheta-Martinez, Encarna, Lovera, Silvia, Lelli, Moreno, López-Méndez, Blanca, Marenchino, Marco, Campos-Olivas, Ramón, Gervasio, Francesco Luigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834493/
https://www.ncbi.nlm.nih.gov/pubmed/27087366
http://dx.doi.org/10.1038/srep24439

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834493/
https://www.ncbi.nlm.nih.gov/pubmed/27087366
http://dx.doi.org/10.1038/srep24439

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