Orthogonal ring-closing alkyne and olefin metathesis for the synthesis of small GTPase-targeting bicyclic peptides

Bicyclic peptides are promising scaffolds for the development of inhibitors of biological targets that proved intractable by typical small molecules. So far, access to bioactive bicyclic peptide architectures is limited due to a lack of appropriate orthogonal ring-closing reactions. Here, we report...

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Detalles Bibliográficos
Autores principales: Cromm, Philipp M., Schaubach, Sebastian, Spiegel, Jochen, Fürstner, Alois, Grossmann, Tom N., Waldmann, Herbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834642/
https://www.ncbi.nlm.nih.gov/pubmed/27075966
http://dx.doi.org/10.1038/ncomms11300

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834642/
https://www.ncbi.nlm.nih.gov/pubmed/27075966
http://dx.doi.org/10.1038/ncomms11300

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