Design, synthesis, in silico toxicity prediction, molecular docking, and evaluation of novel pyrazole derivatives as potential antiproliferative agents

A new series of pyrazole derivatives were designed by docking into vascular endothelial growth factor receptor-2 (VEGFR-2) kinase active site. The designed compounds were synthesized and evaluated for in vitro antiproliferative activity against HT-29 colon and PC-3 prostate cancer cell lines, and an...

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Detalles Bibliográficos
Autores principales: Ravula, Parameshwar, Vamaraju, Harinadha Babu, Paturi, Manichandrika, Chandra JN, Narendra Sharath, Kolli, Swetha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Leibniz Research Centre for Working Environment and Human Factors 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834670/
https://www.ncbi.nlm.nih.gov/pubmed/27103897
http://dx.doi.org/10.17179/excli2016-103

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834670/
https://www.ncbi.nlm.nih.gov/pubmed/27103897
http://dx.doi.org/10.17179/excli2016-103

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