Xyloketal-derived small molecules show protective effect by decreasing mutant Huntingtin protein aggregates in Caenorhabditis elegans model of Huntington’s disease

Huntington’s disease is an autosomal-dominant neurodegenerative disorder, with chorea as the most prominent manifestation. The disease is caused by abnormal expansion of CAG codon repeats in the IT15 gene, which leads to the expression of a glutamine-rich protein named mutant Huntingtin (Htt). Becau...

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Detalles Bibliográficos
Autores principales: Zeng, Yixuan, Guo, Wenyuan, Xu, Guangqing, Wang, Qinmei, Feng, Luyang, Long, Simei, Liang, Fengyin, Huang, Yi, Lu, Xilin, Li, Shichang, Zhou, Jiebin, Burgunder, Jean-Marc, Pang, Jiyan, Pei, Zhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835117/
https://www.ncbi.nlm.nih.gov/pubmed/27110099
http://dx.doi.org/10.2147/DDDT.S94666

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835117/
https://www.ncbi.nlm.nih.gov/pubmed/27110099
http://dx.doi.org/10.2147/DDDT.S94666

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