Nexavar/Stivarga and Viagra Interact to Kill Tumor Cells

We determined whether the multi‐kinase inhibitor sorafenib or its derivative regorafenib interacted with phosphodiesterase 5 (PDE5) inhibitors such as Viagra (sildenafil) to kill tumor cells. PDE5 and PDGFRα/β were over‐expressed in liver tumors compared to normal liver tissue. In multiple cell type...

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Detalles Bibliográficos
Autores principales: Tavallai, Mehrad, Hamed, Hossein A., Roberts, Jane L., Cruickshanks, Nichola, Chuckalovcak, John, Poklepovic, Andrew, Booth, Laurence, Dent, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Original Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835179/
https://www.ncbi.nlm.nih.gov/pubmed/25704960
http://dx.doi.org/10.1002/jcp.24961

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835179/
https://www.ncbi.nlm.nih.gov/pubmed/25704960
http://dx.doi.org/10.1002/jcp.24961

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