Cargando…

Nexavar/Stivarga and Viagra Interact to Kill Tumor Cells

We determined whether the multi‐kinase inhibitor sorafenib or its derivative regorafenib interacted with phosphodiesterase 5 (PDE5) inhibitors such as Viagra (sildenafil) to kill tumor cells. PDE5 and PDGFRα/β were over‐expressed in liver tumors compared to normal liver tissue. In multiple cell type...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tavallai, Mehrad, Hamed, Hossein A., Roberts, Jane L., Cruickshanks, Nichola, Chuckalovcak, John, Poklepovic, Andrew, Booth, Laurence, Dent, Paul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2015
Materias:	Original Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835179/ https://www.ncbi.nlm.nih.gov/pubmed/25704960 http://dx.doi.org/10.1002/jcp.24961

Ejemplares similares

GRP78/Dna K Is a Target for Nexavar/Stivarga/Votrient in the Treatment of Human Malignancies, Viral Infections and Bacterial Diseases
por: Roberts, Jane L., et al.
Publicado: (2015)

OSU‐03012 and Viagra Treatment Inhibits the Activity of Multiple Chaperone Proteins and Disrupts the Blood–Brain Barrier: Implications for Anti‐Cancer Therapies
por: Booth, Laurence, et al.
Publicado: (2015)

Multi-kinase inhibitors interact with sildenafil and ERBB1/2/4 inhibitors to kill tumor cells in vitro and in vivo
por: Booth, Laurence, et al.
Publicado: (2016)

Rationally Repurposing Ruxolitinib (Jakafi(®)) as a Solid Tumor Therapeutic
por: Tavallai, Mehrad, et al.
Publicado: (2016)

Ruxolitinib synergizes with DMF to kill via BIM+BAD-induced mitochondrial dysfunction and via reduced SOD2/TRX expression and ROS
por: Tavallai, Mehrad, et al.
Publicado: (2016)

Histone deacetylase inhibitors restore toxic BH3 domain protein expression in anoikis-resistant mammary and brain cancer stem cells, thereby enhancing the response to anti-ERBB1/ERBB2 therapy
por: Cruickshanks, Nichola, et al.
Publicado: (2013)

Axitinib and HDAC Inhibitors Interact to Kill Sarcoma Cells
por: Roberts, Jane L., et al.
Publicado: (2021)

[Pemetrexed + Sorafenib] lethality is increased by inhibition of ERBB1/2/3-PI3K-NFκB compensatory survival signaling
por: Booth, Laurence, et al.
Publicado: (2016)

Fingolimod Augments Monomethylfumarate Killing of GBM Cells
por: Dent, Paul, et al.
Publicado: (2020)

Curcumin interacts with sildenafil to kill GI tumor cells via endoplasmic reticulum stress and reactive oxygen/ nitrogen species
por: Roberts, Jane L., et al.
Publicado: (2017)

The afatinib resistance of in vivo generated H1975 lung cancer cell clones is mediated by SRC/ERBB3/c-KIT/c-MET compensatory survival signaling
por: Booth, Laurence, et al.
Publicado: (2016)

Corrigendum: Fingolimod Augments Monomethylfumarate Killing of GBM Cells
por: Dent, Paul, et al.
Publicado: (2020)

The HDAC inhibitor AR42 interacts with pazopanib to kill trametinib/dabrafenib-resistant melanoma cells in vitro and in vivo
por: Booth, Laurence, et al.
Publicado: (2017)

Regorafenib (Stivarga) pharmacologically targets epithelial-mesenchymal transition in colorectal cancer
por: Fan, Li-Ching, et al.
Publicado: (2016)

SILDENAFIL (VIAGRA) AND THE HEART
por: Chamsi-Pasha, Hassan
Publicado: (2001)

Nexavar(®)-related adverse reactions: Calabrian (Italy) experience for sorafenib exposition in 2012
por: Cilurzo, Felisa, et al.
Publicado: (2013)

The Lethality of [Pazopanib + HDAC Inhibitors] Is Enhanced by Neratinib
por: Booth, Laurence, et al.
Publicado: (2019)

PDE5 inhibitors enhance the lethality of [pemetrexed + sorafenib]
por: Booth, Laurence, et al.
Publicado: (2017)

Metabolism of Histone Deacetylase Proteins Opsonizes Tumor Cells to Checkpoint Inhibitory Immunotherapies
por: Dent, Paul, et al.
Publicado: (2019)

Viagra : una guía sobre el fármaco que estimula la potencia sexual /
por: Vaughan, Susan C.
Publicado: (1998)

Combining histone deacetylase inhibitors with MDA-7/IL-24 enhances killing of renal carcinoma cells
por: Hamed, Hossein A, et al.
Publicado: (2013)

GZ17-6.02 kills prostate cancer cells in vitro and in vivo
por: Booth, Laurence, et al.
Publicado: (2022)

HDAC inhibitors enhance the immunotherapy response of melanoma cells
por: Booth, Laurence, et al.
Publicado: (2017)

PDE5 inhibitors enhance the lethality of pemetrexed through inhibition of multiple chaperone proteins and via the actions of cyclic GMP and nitric oxide
por: Booth, Laurence, et al.
Publicado: (2016)

Physicians’ Moral Dilemmas in the Age of Viagra
por: Ayalon, Liat
Publicado: (2020)

The Economics of Viagra Revisited: The Price Is Right
por: Agochukwu-Mmonu, Nnenaya, et al.
Publicado: (2021)

Tips de sexualidad Viagra : da más firmeza.

Viagra : claves de la campaña de comunicación que convirtió a este fármaco en un fenómeno social /
por: Pescador Martín, Mercedes
Publicado: (2001)

Viagra : todo lo que necesitas saber sobre el fármaco que revolucionará la vida sexual en este fin de siglo /
por: Katzenstein, Larry
Publicado: (1998)

Sildenafil (Viagra) sensitizes prostate cancer cells to doxorubicin-mediated apoptosis through CD95
por: Das, Anindita, et al.
Publicado: (2015)

Inhibition of heat shock proteins increases autophagosome formation, and reduces the expression of APP, Tau, SOD1 G93A and TDP-43
por: Dent, Paul, et al.
Publicado: (2021)

Multi-kinase inhibitors can associate with heat shock proteins through their NH(2)-termini by which they suppress chaperone function
por: Booth, Laurence, et al.
Publicado: (2016)

Online Prescribing of Sildanefil (Viagra) on the World Wide Web
por: Eysenbach, Gunther
Publicado: (1999)

Methamphetamine and Viagra Use: Relationship to Sexual Risk Behaviors
por: Fisher, Dennis G., et al.
Publicado: (2009)

Ups and Downs of Viagra: Revisiting Ototoxicity in the Mouse Model
por: Au, Adrian, et al.
Publicado: (2013)

GZ17-6.02 and axitinib interact to kill renal carcinoma cells
por: Booth, Laurence, et al.
Publicado: (2022)

AR12 (OSU-03012) suppresses GRP78 expression and inhibits SARS-CoV-2 replication
por: Rayner, Jonathan O., et al.
Publicado: (2020)

GZ17-6.02 and palbociclib interact to kill ER+ breast cancer cells
por: Booth, Laurence, et al.
Publicado: (2022)

GZ17-6.02 and Doxorubicin Interact to Kill Sarcoma Cells via Autophagy and Death Receptor Signaling
por: Booth, Laurence, et al.
Publicado: (2020)

AR12 increases BAG3 expression which is essential for Tau and APP degradation via LC3-associated phagocytosis and macroautophagy
por: Dent, Paul, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_uisl53egh8c6ge5n8amcp44k9g