Exploration of the binding modes of l-asparaginase complexed with its amino acid substrates by molecular docking, dynamics and simulation

Acute lymphocytic leukemia (ALL) is an outrageous disease worldwide. l-Asparagine (l-Asn) and l-glutamine (l-Gln) deamination plays crucial role in ALL treatment. Role of Erwinaze(®) (l-asparaginase from Erwinia chrysanthemi) in regulation of l-Asn and l-Gln has been confirmed by the experimental st...

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Detalles Bibliográficos
Autores principales: Reddy, Erva Rajeswara, Babu, Rajulapati Satish, Chandrasai, Potla Durthi, Madhuri, Pola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835421/
https://www.ncbi.nlm.nih.gov/pubmed/28330175
http://dx.doi.org/10.1007/s13205-016-0422-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835421/
https://www.ncbi.nlm.nih.gov/pubmed/28330175
http://dx.doi.org/10.1007/s13205-016-0422-x

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