ATM mediates spermidine-induced mitophagy via PINK1 and Parkin regulation in human fibroblasts

The ATM (ataxia telangiectasia mutated) protein has recently been proposed to play critical roles in the response to mitochondrial dysfunction by initiating mitophagy. Here, we have used ATM-proficient GM00637 cells and ATM-deficient GM05849 cells to investigate the mitophagic effect of spermidine a...

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Detalles Bibliográficos
Autores principales: Qi, Yongmei, Qiu, Qian, Gu, Xueyan, Tian, Yihong, Zhang, Yingmei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835770/
https://www.ncbi.nlm.nih.gov/pubmed/27089984
http://dx.doi.org/10.1038/srep24700

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835770/
https://www.ncbi.nlm.nih.gov/pubmed/27089984
http://dx.doi.org/10.1038/srep24700

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