Transient activation of human cytomegalovirus lytic gene expression during latency allows cytotoxic T cell killing of latently infected cells

Human cytomegalovirus (HCMV) latency in the myeloid lineage is maintained by repressive histone modifications around the major immediate early promoter (MIEP), which results in inhibition of the lytic viral life cycle. We now show that pharmacological inhibition of histone deacetylases (HDACs) relie...

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Detalles Bibliográficos
Autores principales: Krishna, B. A., Lau, B., Jackson, S. E., Wills, M. R., Sinclair, J. H., Poole, E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835774/
https://www.ncbi.nlm.nih.gov/pubmed/27091512
http://dx.doi.org/10.1038/srep24674

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835774/
https://www.ncbi.nlm.nih.gov/pubmed/27091512
http://dx.doi.org/10.1038/srep24674

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