Isoform switching and exon skipping induced by the DNA methylation inhibitor 5-Aza-2′-deoxycytidine

DNA methylation in gene promoters leads to gene silencing and is the therapeutic target of methylation inhibitors such as 5-Aza-2′-deoxycytidine (5-Aza-CdR). By analyzing the time series RNA-seq data (days 5, 9, 13, 17) obtained from human bladder cells exposed to 5-Aza-CdR with 0.1 uM concentration...

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Detalles Bibliográficos
Autores principales: Ding, Xiao-Lei, Yang, Xiaojing, Liang, Gangning, Wang, Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835787/
https://www.ncbi.nlm.nih.gov/pubmed/27090213
http://dx.doi.org/10.1038/srep24545

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835787/
https://www.ncbi.nlm.nih.gov/pubmed/27090213
http://dx.doi.org/10.1038/srep24545

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