Inducible T-cell co-stimulator ligand (ICOSL) blockade leads to selective inhibition of anti-KLH IgG responses in subjects with systemic lupus erythematosus

OBJECTIVES: To evaluate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of single-dose and multiple-dose administration of AMG 557, a human anti-inducible T cell co-stimulator ligand (ICOSL) monoclonal antibody, in subjects with systemic lupus erythematosus (SLE). METHODS:...

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Detalles Bibliográficos
Autores principales: Sullivan, B A, Tsuji, W, Kivitz, A, Peng, J, Arnold, G E, Boedigheimer, M J, Chiu, K, Green, C L, Kaliyaperumal, A, Wang, C, Ferbas, J, Chung, J B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2016
Materias:
Clinical Trials and Drug Discovery
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836284/
https://www.ncbi.nlm.nih.gov/pubmed/27099766
http://dx.doi.org/10.1136/lupus-2016-000146

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836284/
https://www.ncbi.nlm.nih.gov/pubmed/27099766
http://dx.doi.org/10.1136/lupus-2016-000146

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