Copper and Zinc Interactions with Cellular Prion Proteins Change Solubility of Full-Length Glycosylated Isoforms and Induce the Occurrence of Heterogeneous Phenotypes

Prion diseases are characterized biochemically by protein aggregation of infectious prion isoforms (PrP(Sc)), which result from the conformational conversion of physiological prion proteins (PrP(C)). PrP(C) are variable post-translationally modified glycoproteins, which exist as full length and as a...

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Detalles Bibliográficos
Autores principales: Brim, Svetlana, Groschup, Martin H., Kuczius, Thorsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836684/
https://www.ncbi.nlm.nih.gov/pubmed/27093554
http://dx.doi.org/10.1371/journal.pone.0153931

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836684/
https://www.ncbi.nlm.nih.gov/pubmed/27093554
http://dx.doi.org/10.1371/journal.pone.0153931

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