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Copper and Zinc Interactions with Cellular Prion Proteins Change Solubility of Full-Length Glycosylated Isoforms and Induce the Occurrence of Heterogeneous Phenotypes
Prion diseases are characterized biochemically by protein aggregation of infectious prion isoforms (PrP(Sc)), which result from the conformational conversion of physiological prion proteins (PrP(C)). PrP(C) are variable post-translationally modified glycoproteins, which exist as full length and as a...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836684/ https://www.ncbi.nlm.nih.gov/pubmed/27093554 http://dx.doi.org/10.1371/journal.pone.0153931 |