Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification

Broad spectrum antiviral drugs targeting host processes could potentially treat a wide range of viruses while reducing the likelihood of emergent resistance. Despite great promise as therapeutics, such drugs remain largely elusive. Here we use parallel genome-wide high-coverage shRNA and CRISPR-Cas9...

Descripción completa

Detalles Bibliográficos
Autores principales: Deans, Richard M., Morgens, David W., Ökesli, Ayşe, Pillay, Sirika, Horlbeck, Max A., Kampmann, Martin, Gilbert, Luke A., Li, Amy, Mateo, Roberto, Smith, Mark, Glenn, Jeffrey S., Carette, Jan E., Khosla, Chaitan, Bassik, Michael C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836973/
https://www.ncbi.nlm.nih.gov/pubmed/27018887
http://dx.doi.org/10.1038/nchembio.2050

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836973/
https://www.ncbi.nlm.nih.gov/pubmed/27018887
http://dx.doi.org/10.1038/nchembio.2050

Ejemplares similares