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Late stages of T cell maturation in the thymus involve NF-κB and tonic type I interferon signaling
Positive selection occurs in the thymic cortex, but critical maturation events occur later in the medulla. We defined the precise stage at which T cells acquire competence to proliferate and emigrate. Transcriptome analysis of late gene changes suggested roles for NF-κB and interferon (IFN) signalin...
Autores principales: | Xing, Yan, Wang, Xiaodan, Jameson, Stephen C., Hogquist, Kristin A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837029/ https://www.ncbi.nlm.nih.gov/pubmed/27043411 http://dx.doi.org/10.1038/ni.3419 |
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