AIG1 and ADTRP are Atypical Integral Membrane Hydrolases that Degrade Bioactive FAHFAs

Enzyme classes may contain outlier members that share mechanistic, but not sequence or structural relatedness with more common representatives. The functional annotation of such exceptional proteins can be challenging. Here, we use activity-based profiling to discover that the poorly characterized m...

Descripción completa

Detalles Bibliográficos
Autores principales: Parsons, William H, Kolar, Matthew J, Kamat, Siddhesh S, Cognetta, Armand B, Hulce, Jonathan J, Saez, Enrique, Kahn, Barbara B, Saghatelian, Alan, Cravatt, Benjamin F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837090/
https://www.ncbi.nlm.nih.gov/pubmed/27018888
http://dx.doi.org/10.1038/nchembio.2051

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837090/
https://www.ncbi.nlm.nih.gov/pubmed/27018888
http://dx.doi.org/10.1038/nchembio.2051

Ejemplares similares